Vaccinare
I vantaggi dei vaccini combinati
ADVANTAGES OF COMBINED VACCINES
GIORGIO BARTOLOZZI
Dipartimento di Pediatria, Università di Firenze
Settembre 1998 - pagg. 461 -463
Abstract
The introduction of combined vaccines can
significantly improve immunization coverage
and reduce costs. The Author reviews
the state-of-the-art of combined vaccines.
At present, given its insufficient immunogenicity,
the combined DTP-Hib vaccine cannot
be recommended. Immunogenicity of
combined DTPa-polio vaccine and of DTPa-
HBV vaccine are, on the contrary, quite satisfactory.
The latter can be used with all
the current immunization schedules and
appears particularly advantageous.
Classificazione MeSH
Bibliografia
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2. Bartolozzi G: Vaccini combinati per nuove vaccinazioni. Vaccinazione 2000 6, n.31, 1-3, 1994.
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4. Centers for Disease Control and Prevention (CDC): FDA approval of a Haemophilus influenzae b conjugate vaccine combined by reconstruction with an acellular pertussis vaccine. MMWR 45, 993-5, 1996.
5. Dagan R, Igbaria K, Piglansky L, et al: Safety and immunogenicity of a combined pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliovirus and Haemophilus influenzae type b-tetanus conjugate vaccine in infants, compared with a whole cell pertussis pentavalent vaccine. Pediatr Infect Dis 16, 113-21, 1997.
6. Diez-Delgado J, Dal-Ré R, Lorente M, et al: Hepatitis B component not interfere with the immune response to diphtheria, tetanus and whole-cell Bordetella pertussis components of a quadrivalent (DTPw-HB) vaccine: a controlled trial in healthy infants. Vaccine 15, 1418-22, 1997.
7. Edwards ME, Decker MD: Combination vaccines consisting of acellular pertussis vaccines. Pediatr Infect Dis J 16, S97-102, 1997.
8. Eskola J, Olander RM, Hovi T, et al: Randomized trial of the effect of co-administration with acellular pertussis DTP vaccine on immunogenicity of Haemophilus influenzae type b conjugate vaccine. Lancet 348, 1688- 92, 1996.
9. Giammanco G, Moiraghi A, Zotti C, et al: Safety and immunogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B vaccine administered according to two different primary vaccination schedules. Vaccine 16, 722-6, 1998.
10. Usonis V, Bakasenas V, Willems P, Clemens R: Feasibility study of a combined diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine, and comparison of clinical reactions and immune responses with diphtheria-tetanus-acellular pertussis (DTPa) and hepatitis B vaccines applied as mixed or injected into separate limbs. Vaccine 15, 1680-6, 1997.
2. Bartolozzi G: Vaccini combinati per nuove vaccinazioni. Vaccinazione 2000 6, n.31, 1-3, 1994.
3. Bartolozzi G, Longo G: Thimerosal, “allergia” all’aspirina e vaccini. Medico e Bambino 15, 115-6, 1996.
4. Centers for Disease Control and Prevention (CDC): FDA approval of a Haemophilus influenzae b conjugate vaccine combined by reconstruction with an acellular pertussis vaccine. MMWR 45, 993-5, 1996.
5. Dagan R, Igbaria K, Piglansky L, et al: Safety and immunogenicity of a combined pentavalent diphtheria, tetanus, acellular pertussis, inactivated poliovirus and Haemophilus influenzae type b-tetanus conjugate vaccine in infants, compared with a whole cell pertussis pentavalent vaccine. Pediatr Infect Dis 16, 113-21, 1997.
6. Diez-Delgado J, Dal-Ré R, Lorente M, et al: Hepatitis B component not interfere with the immune response to diphtheria, tetanus and whole-cell Bordetella pertussis components of a quadrivalent (DTPw-HB) vaccine: a controlled trial in healthy infants. Vaccine 15, 1418-22, 1997.
7. Edwards ME, Decker MD: Combination vaccines consisting of acellular pertussis vaccines. Pediatr Infect Dis J 16, S97-102, 1997.
8. Eskola J, Olander RM, Hovi T, et al: Randomized trial of the effect of co-administration with acellular pertussis DTP vaccine on immunogenicity of Haemophilus influenzae type b conjugate vaccine. Lancet 348, 1688- 92, 1996.
9. Giammanco G, Moiraghi A, Zotti C, et al: Safety and immunogenicity of a combined diphtheria-tetanus-acellular pertussis-hepatitis B vaccine administered according to two different primary vaccination schedules. Vaccine 16, 722-6, 1998.
10. Usonis V, Bakasenas V, Willems P, Clemens R: Feasibility study of a combined diphtheria-tetanus-acellular pertussis-hepatitis B (DTPa-HBV) vaccine, and comparison of clinical reactions and immune responses with diphtheria-tetanus-acellular pertussis (DTPa) and hepatitis B vaccines applied as mixed or injected into separate limbs. Vaccine 15, 1680-6, 1997.