Rivista di formazione e aggiornamento professionale del pediatra e del medico di base, fondata nel 1982. In collaborazione con l'Associazione Culturale Pediatri.
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Vaccinazioni pediatriche: le domande difficili

Franco Giovanetti
Dipartimento di Prevenzione, ASL CN2 Alba Bra, Regione Piemonte

Settembre 2017

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Classificazione MeSH
Drug Safety (21) Immunization Programs (91) Immunization Schedule (51) Vaccines (31)
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Bibliografia

Bibliografia
  • AAP – American Academy of Pediatrics (Task Force on Sudden Infant Death Syndrome, Moon RY) Policy Statement. SIDS and Other Sleep-Related Infant Deaths: Expansion of Recommendations for a Safe Infant Sleeping Environment. Pediatrics 2011;128(5):1030-9.
  • ACIP, Advisory Committee on Immunization Practices. General recommendations on immunization: recommendations of the Advisory Committee on Immunization Practices 2011;60(2):1-60.
  • AIFA. Osservatorio Nazionale sull’impiego dei Medicinali. L’uso dei farmaci in Italia. Rapporto Nazionale anno 2015. Roma, giugno 2016.
  • Albano A, Salvaggio L. Manuale di Igiene. Piccin-Nuova Libraria (Eds), 1987.
  • Hauser WA. The prevalence and incidence of convulsive disorders in children. Epilepsia 1994;35 Suppl 2:S1-6.
  • Anderson HR, Poloniecki JD, Strachan DP, Beasley R, Björkstén B, Asher MI; ISAAC Phase 1 Study Group. Immunization and symptoms of atopic disease in children: results from the International Study of Asthma and Allergies in Childhood. Am J Public Health 2001;91(7):1126-9.
  • Andrews N, Miller E, Grant A, Stowe J, Osborne V, Taylor B. Thimerosal exposure in infants and developmental disorders: a retrospective cohort study in the United kingdom does not support a causal association. Pediatrics 2004;114(3):584-91.
  • ANSM- Agence Nationale de Sécurité du Médicament et des Produits de Santé. Comite Scientifique Specialise Temporaire. Évaluation toxicologique des métaux dans les vaccins - n° 2. Séance du 13/05/2016 de 13H30 à 16h30 en salle A011.
  • Ascherio A, Zhang SM, Hernán MA, et al. Hepatitis B vaccination and the risk of multiple sclerosis. New Engl J Med 2001;344(5):327-32.
  • Assael BM. Il favoloso innesto. Storia sociale della vaccinazione. Laterza (Eds). Bari, 1995.
  • Austin DW, Shandley KA, Palombo EA. Mercury in vaccines from the Australian childhood immunization program schedule. J Toxicol Environ Health A. 2010;73(10):637-40.
  • Baraff LJ1, Shields WD, Beckwith L, et al. Infants and children with convulsions and hypotonic-hyporesponsive episodes following Diphtheria-Tetanus-Pertussis immunization: follow-up evaluation. Pediatrics 1988;81(6):789-94.
  • Barlow WE, Davis RL, Glasser JW, et al; Centers for Disease Control and Prevention Vaccine Safety Datalink Working Group. The risk of seizures after receipt of whole-cell pertussis or measles, mumps, and rubella vaccine. N Engl J Med 2001;345(9):656-61.
  • Berkovic SF, Harkin L, McMahon JM, et al. De-novo mutations of the sodium channel gene SCN1A in alleged vaccine encephalopathy: a retrospective study. Lancet Neurol, 2006;5(6):488–92.
  • Bernsen RM, de Jongste JC, Koes BW, Aardoom HA, van der Wouden JC. Diphtheria tetanus pertussis poliomyelitis vaccination and reported atopic disorders in 8-12-year-old children. Vaccine 2006;24(12):2035-42.
  • Bolt F, Cassiday P, Tondella ML, et al. Multilocus sequence typing identifies evidence for recombination and two distinct lineages of Corynebacterium diphtheriae. J Clin Microbiol 2010;48(11):4177-85.
  • Borrow R, Balmer P, Roper MH. Immunological basis for immunization series. Module 3 – Tetanus Update 2006. World Health Organization, 2007.
  • Chen RT, Moses JM, Markowitz LE, Orenstein WA. Adverse events following measles-mumps-rubella and measles vaccinations in college students. Vaccine 1991;9(5):297-9.
  • Chess S, Fernandez P, Korn S. Behavioral consequences of congenital rubella. J Pediatr 1978;93(4):699-703.
  • Confavreux C, Suissa S, Saddier P, Bourdès V, Vukusic S; Vaccines in Multiple Sclerosis Study Group. Vaccinations and the risk of relapse in multiple sclerosis. New Engl J Med 2001;344(5):319-26.
  • Conyn-van Spaendonck MA, Oostvogel PM, van Loon AM, van Wijngaarden JK, Kromhout D. Circulation of poliovirus during the poliomyelitis outbreak in The Netherlands in 1992-1993. Am J Epidemiol 1996;143(9):929-35.
  • Conway, PL. Microbial ecology of the human large intestine. In: Human Colonic Bacteria. Gibson GR and Macfarlane GT Eds). CRC Press, Boca Raton, FL 1995, pp. 1-24.
  • Crovari P, Principi N. Le vaccinazioni. Pacini Editore, 2001.
  • Dales L, Hammer SJ, Smith NJ. Time trends in autism and in MMR immunization coverage in California. JAMA 2001;285(9):1183–5.
  • De Jesus NH. Epidemics to eradication: the modern history of poliomyelitis. Virol J 2007;4:70.
  • Demicheli V, Rivetti A, Debalini MG, Di Pietrantonj C. Vaccines for measles, mumps and rubella in children. Cochrane Database Syst Rev 2012;(2):CD004407.
  • DeStefano F, Mullooly JP, Okoro CA, et al. Childhood immunizations, Vaccination Timing, and risk of Type 1 Diabetes Mellitus. Pediatrics 2001;108(6):E112.
  • DeStefano F, Gu D, Kramarz P, et al.; Vaccine Safety Datalink Research Group. Childhood vaccinations and the risk of asthma. Pediatr Infect Dis J 2002;21(6):498–504.
  • DeStefano F, Bhasin TK, Thompson WW, Yeargin-Allsopp M, Boyle C. Age at first measles-mumps-rubella vaccination in children with autism and school matched control subjects: a population-based study in metropolitan Atlanta. Pediatrics 2004;113(2):259-66.
  • DeStefano F, Price CS, Weintraub ES. Increasing exposure to antibody-stimulating proteins and polysaccharides in vaccines is not associated with risk of autism. J Pediatr 2013;163(2):561-7.
  • de Vries RD, de Swart RL. Measles immune suppression: functional impairment or numbers game? PLoS Pathog 2014;10(12):e1004482.
  • DeWilde S, Carey IM, Richards N, Hilton SR, Cook DG. Do children who become autistic consult more often after MMR vaccination? Br J Gen Pract 2001;51(464):226-7.
  • Dippe H. Infektionskrankheiten. Leipzig 1896, Verlagsbuchhandlung Weber.
  • Dittmann S. Resurgence of communicable diseases in Europe. World Health – The magazine of the World Health Organization. 1997 (1) January February: 24-25.
  • Duclos P, Ward BJ. Measles Vaccines: A Review of Adverse Events. Drug Safety 1998;19(6):435-54.
  • Duderstadt SK, Rose CE Jr, Real TM, et al. Vaccination and risk of type 1 diabetes mellitus in active component U.S. Military, 2002–2008. Vaccine 2012;30(4):813-9.
  • Durrheim DN, Cashman P. Addressing the immunization coverage paradox: A matter of children's rights and social justice. Clin Ther 2010;32(8):1496-8.
  • ECDC, European Centre for Disease Prevention and Control. Wild-type poliovirus 1 transmission in Israel – what is the risk to the EU/EEA? Stockholm, September 2013.
  • ECDC, European Centre for Disease Prevention and Control. Rapid risk assessment. A case of diphtheria in Spain. 15.06.2015.Stockholm, 2015
  • ECDC, European Centre for Disease Prevention and Control. Rapid risk assessment. A fatal case of diphtheria in Belgium. 24.03.2016 Stockholm, 2016.
  • Esposito S, Tansey S, Thompson A, et al. Safety and immunogenicity of a 13-valent pneumococcal conjugate vaccine compared to those of a 7-valent pneumococcal conjugate vaccine given as a three-dose series with routine vaccines in healthy infants and toddlers. Clin Vaccine Immunol 2010;17(6):1017-26.
  • Fair E, Murphy TV, Golaz A, Wharton M. Philosophic Objection to Vaccination as a Risk for Tetanus Among Children Younger than 15 years. Pediatrics 2002;109(1):E2.
  • Farrington P, Miller E. Measles vaccination as a risk factor for inflammatory bowel disease [letter]. Lancet 1995;345(8961):1362.
  • Farrington CP, Miller E, Taylor B. MMR and autism: further evidence against a causal association. Vaccine 2001;19(27):3632-5.
  • Feeney M, Clegg A, Winwood P, Snook J. A case-control study of measles vaccination and inflammatory bowel disease. Lancet 1997;350(9080):764-6.
  • Filia A, Brenna A, Panà A, et al. Ricoveri per morbillo in Italia nel 2002: valutazione dell’impatto in termini di salute e di costi. Rapporti ISTISAN 2005
  • Filia A, Bella A, von Hunolstein C, et al. Tetanus in Italy 2001-2010: a continuing threat in older adults. Vaccine 2014;32(6):639-44.
  • Fleming PJ, Blair PS, Platt MW, Tripp J, Smith IJ, Golding J. The UK accelerated immunisation programme and sudden unexpected death in infancy: case-control study. BMJ 2001;322(7290):822.
  • Fombonne E, Chakrabarti S. No evidence for a new variant of measles-mumps-rubella–induced autism. Pediatrics 2001;108(4):E58.
  • Fombonne E, Zakarian R, Bennett A, Meng L, McLean-Heywood D. Pervasive Developmental Disorders in Montreal, Quebec, Canada: Prevalence and Links with Immunizations. Pediatrics 2006;118(1):139-50.
  • Gangarosa EJ, Galazka AM, Wolfe CR, et al. Impact of anti-vaccine movements on pertussis control: the untold story. Lancet 1998;351(9099):356-61.
  • Gatti AM, Montanari S. New Quality-Control Investigations on Vaccines: Micro- and Nanocontamination. Int J Vaccines Vaccin 2016;4(1):00072.
  • Giordano C, Bardi U, Garbini D, Suman M. Analysis of particulate pollution on foodstuff and other items by Environmental Scanning Electron Microscopy. Microsc Res Tech 2011;74(10):931-5.
  • Giovanetti F, Pellegrino A. A case of tetanus in a child whose parents refused immunisation – Piedmont Region, Italy, 2006. Euro Surveill 2007;12(25).
  • Godlee F, Smith J, Marcovitch H. Wakefield’s article linking MMR vaccine and autism was fraudulent. BMJ 2011;342:c7452.
  • Goldblatt D, Miller E. Nonspecific Effects of Vaccines. JAMA 2014;311(8):804-5.
  • Graves P, Barriga KJ, Norris JM, et al. Lack of association Between Early Childhood Immunizations and Beta-cell autoimmunity. Diabetes Care 1999;22(10):1694-7.
  • Grüber C, Nilsson L, Bjorksten B. Do early childhood immunizations influence the development of atopy and do they cause allergic reactions? Pediatr Allergy Immunol 2001;12<(6):296-311.
  • Grüber C, Illi S, Lau S, et al.; MAS-90 Study Group. Transient suppression of atopy in early childhood is associated with high vaccination coverage. Pediatrics 2003 Mar;111(3):e282-8.
  • Grüber C1, Warner J, Hill D, Bauchau V; EPAAC Study Group. Early atopic disease and early childhood immunization--is there a link? Allergy 2008;63(11):1464-72.
  • Guilfoile P. Deadly diseases and epidemics: Diphtheria. Chelsea House, New York 2009.
  • Haga Y, Funakoshi O, Kuroe K, et al. Absence of measles viral genomic sequence in intestinal tissues from Crohn’s disease by nested polymerase chain reaction. Gut 1996;38(2):211-5.
  • Hansen SN, Schendel DE, Parner ET. Explaining the increase in the prevalence of autism spectrum disorders: the proportion attributable to changes in reporting practices. JAMA Pediatr. 2015;169:56-62.
  • Heininger U, Kleemann WJ, Cherry JD; Sudden Infant Death Syndrome Study Group. A controlled study of the relationship between Bordetella pertussis infections and sudden unexpected deaths among German infants. Pediatrics. 2004;114(1):e9-15.
  • Henderson J, North K, Griffiths M. et a. Pertussis vaccination and wheezing illnesses in young children: a prospective cohort study. BMJ 1999;318:1173–1176.
  • Hennino A, Cornu C, Rozieres A et al. Influence of measles vaccination on the progression of atopic dermatitis in infants. Pediatr Allergy Immunol 2007;18:385-90.
  • Heron J, Golding J, and ALSPAC Study Team. Thimerosal exposure in infants and developmental disorders: a prospective cohort study in the United Kingdom does not show a causal association. Pediatrics. 2004;114:577-583.
  • Hoffman HJ, Hunter JC, Damus K, et al. Diphtheria-tetanus-pertussis immunization and sudden infant death: results of the National Institute of Child Health and Human Development Cooperative Epidemiological Study of Sudden Infant Death Syndrome risk factors. Pediatrics 1987;79:598–611.
  • Honda H, Shimizu Y, Rutter M. No effect of MMR withdrawal on the incidence of autism: a total population study. J Child Psychol Psychiatry 2005;46:572-9.
  • Huang WT, Paul M. Gargiullo, Karen R. Broder et al. Lack of Association Between Acellular Pertussis Vaccine and Seizures in Early Childhood. Pediatrics 2010;126:263-269.
  • Hviid A, et al. Association between thimerosal-containing vaccine and autism. Journal of the American Medical Association 2003;290:1763-1766.
  • Hviid A, Stellfeld M, Wohlfahrt J, Melbye M. Childhood Vaccination and Type 1 Diabetes. N Engl J Med 2004;350:1398-1404.
  • Hviid A, Wohlfahrt J, Stellfeld M, Melbye M. Childhood Vaccination and Nontargeted Infectious Disease Hospitalization. JAMA 2005;294:699-705.
  • Institute of Medicine 2012. Adverse effects of vaccines: Evidence and causality. Washington, DC: The National Academies Press.
  • Jain A, Marshall J, Buikema A et al. Autism occurrence by MMR vaccine status among US children with older siblings with and without autism. JAMA 2015;313(15):1534-40.
  • Jefferson T, Demicheli V. No evidence that vaccines cause insulin dependent diabetes mellitus. J. Epidemiol Community Health 1998; 52:674-675.
  • Kaye JA et al. Mumps, measles and rubella vaccine and the incidence of autism recorded by general practitioners: a time trend analysis. BMJ 2001;174:387-390
  • Keith LS, Jones DE, Chou C. Aluminum toxicokinetics regarding infant diet and vaccinations. Vaccine 2002;20:S13–S17.
  • Klein NP, Lewis E, Fireman B et al. Safety of Measles-Containing Vaccines in 1-Year-old Children. Pediatrics. 2015 Jan 5. pii: peds.2014-1822.
  • Langer-Gould A, Qian L, Tartof SY et al. Vaccines and the risk of multiple sclerosis and other central nervous system demyelinating diseases. JAMA Neurol 2014;71:1506-13.
  • Lomer MCE et al. Fine and ultrafine particles in the diet: influence on the mucosal immune response and association with Crohn’s disease. Proceedings of the Nutrition Society 2002, 61: 123-130.
  • Ludlow M, Lemon K, De Vries RD, McQuaid S, Millar E, et al. Measles virus infection of epithelial cells in the macaque upper respiratory tract is mediated by sub-epithelial immune cells. J Virol 2012;87: 4033–4042.
  • Madsen KM, Hviid A, Vestergaard M, et al. A population-based study of measles, mumps, and rubella vaccination and autism. N Engl J Med 2002;347:1477–82.
  • Madsen KM, Lauritsen MB, Pedersen CB, et al. Thimerosal and the occurrence of autism: negative ecological evidence from Danish population-based data. Pediatrics 2003;112:604-6.
  • Maglione MA, Lopamudra D, Raaen L et al. Safety of Vaccines Used for Routine Immunization of US Children: A Systematic Review. Pediatrics 2014 DOI: 10.1542/peds.2014-1079.
  • Mäkelä A, Nuorti JP, Peltola H. Neurologic Disorders After Measles-Mumps-Rubella Vaccination. Pediatrics 2002;110:957 -963.
  • Mandolini D et al. Epidemiologia del tetano in Italia. BEN - Notiziario ISS - Vol.15 - n.3. Marzo 2002 http://www.epicentro.iss.it/ben/pre_2002/marzo02/2.htm
  • Manor Y, Shulman LM, Kaliner E, Hindiyeh M, Ram D, Sofer D, Moran-Gilad J, Lev B, Grotto I, Gamzu R, Mendelson E. Intensified environmental surveillance supporting the response to wild poliovirus type 1 silent circulation in Israel, 2013 . Euro Surveill. 2014;19(7):pii=20708. Available online: http://www.eurosurveillance.org/ViewArticle.aspx?ArticleId=20708
  • Martignon G, Oryszczyn MP, Annesi-Maesano I et al. Does childhood immunization against infectious diseases protect from the development of atopic disease? Pediatr Allergy Immunol. 2005;16:193-200.
  • Matheson MC, Haydn Walters E, Burgess JA et al. Childhood immunization and atopic disease into middle-age--a prospective cohort study. Pediatr Allergy Immunol 2010;21:301-6.
  • Matzkin H and Regev S. Naturally acquired immunity to tetanus toxin in an isolated community. Infect Immun 1985;48:267-268
  • McIntosh AM, McMahon J, Dibbens LM, Iona X, Mulley JC, Scheffer IE, Berkovic SF. Effects of vaccination on onset and outcome of Dravet syndrome: a retrospective study. Lancet Neurol 2010;9:592-8. Epub 2010 May 4.
  • Miller E, Andrews N, Waight P, Taylor B. Bacterial infections, immune overload, and MMR vaccine. Arch Dis Child 2003;88:222-223.
  • Miller E, Andrews N, Waight P et al. Safety and immunogenicity of coadministering a combined meningococcal serogroup C and Haemophilus influenzae type b conjugate vaccine with 7-valent pneumococcal conjugate vaccine and measles, mumps, and rubella vaccine at 12 months of age. Clin Vaccine Immunol. 2011;18:367-72. Epub 2010 Dec 29.
  • Mina MJ, Metcalf CJ, de Swart RL et al. Long-term measles-induced immunomodulation increases overall childhood infectious disease mortality. Science May 2015;348:694-699.
  • Mitchell EA, Stewart AW, Clements M. Immunisation and the sudden infant death syndrome. New Zealand Cot Death Study Group. Arch Dis Child 1995;73:498–501.
  • Mitkus RJ, King DB, Hess MA et al. Updated aluminum pharmacokinetics following infant exposures through diet and vaccination. Vaccine 2011;29:9538-9543.
  • Mullooly J P, Pearson J, Drew L. et al Wheezing, lower respiratory disease and vaccination of full term infants. Pharmacoepidemiol Drug Saf 2002;11:21–30.
  • Murch SH et al. Retraction of an interpretation. The Lancet 2004;363:750.
  • Nakajima K, Dharmage SC, Carlin JB et al. Is childhood immunisation associated with atopic disease from age 7 to 32 years? Thorax 2007;62:270-5. Epub 2006 Nov 7.
  • National Advisory Committee on Immunization. Statement on the recommended use of pentavalent and hexavalent vaccines. CCDR 1 February 2007. Volume 33. ACS-1 http://www.phac-aspc.gc.ca/publicat/ccdr-rmtc/07pdf/acs33-01.pdf
  • National Cancer Institute, 2004. Formaldehyde and Cancer: Questions and Answers www.cancer.gov/cancertopics/factsheet/Risk/formaldehyde
  • Nelson K, Bauman M. Thimerosal and autism? Pediatrics 2003;111:674-679.
  • Nilsson L, Kjellman N, Björkstén B. A randomized controlled trial of the effect of pertussis vaccines on atopic disease. Arch Pediatr Adolesc Med 1998;152:734–738.
  • Offit PA, Quarles J, Gerber MA et al. Addressing Parents’ Concerns: Do Multiple Vaccines Overwhelm or Weaken the Infant’s Immune System? Pediatrics 2002;109:124-129.
  • Offit PA, Kew RK. Addressing Parents’ Concerns: Do Vaccines Contain Harmful Preservatives, Adjuvants, Additives, or Residuals? Pediatrics 2003;112:1394-1401.
  • Offit PA, Director, Vaccine Education Center, Children's Hospital of Philadelphia Source: Q&A, Vol. 2 - Fall 2008 http://www.chop.edu/export/download/pdfs/articles/vaccine-education-center/thimerosal.pdf
  • Offit PA, DeStefano F. Vaccine safety. In: Plotkin S, Orenstein WA, Offit PA (Eds.) Vaccines. Saunders 2013.
  • Orenstein WA, Perry RT, Halsey NA. The Clinical Significance of Measles: A Review. J Infect Dis 2004;189 (Supplement 1): S4-S16.
  • Oostvogel PM, van Mwinjgaarden JK, van der Avoort HGAM et al. Poliomyielitis outbreak in un unvaccinated community in the Netherlands, 1992-93. Lancet 1994;334: 665-70.
  • Otto S, Mahner B, Kadow I, Beck JF, Wiersbitzky SK, Bruns R. General non-specific morbidity is reduced after vaccination within the third month of life--the Greifswald study. J Infect 2000;41:172-5.
  • Pahud BA, Rowhani-Rahbar A, Glaser C et al. Lack of association between childhood immunizations and encephalitis in California, 1998-2008. Vaccine. 2012;30:247-53.
  • Parker SK, Schwartz B, Todd J and Pickering LK. Thimerosal-Containing Vaccines and Autistic Spectrum Disorder: A Critical Review of Published Original Data. Pediatrics 2004;114:793-804.
  • Patja A, Davidkin I, Kurki T, Kallio MJ, Valle M, Peltola H. Serious adverse events after measles-mumps-rubella vaccination during a fourteen-year prospective follow-up. Pediatr Infect Dis J 2000; 19:1127–34.
  • Patriarca PA, Beeler JA. Measles vaccination and inflammatory bowel disease [comment]. Lancet 1995; 345:1062-63.
  • Peltola H, Patja A, Leinikki P, Valle M, Davidkin I, Paunio M. No evidence for measles, mumps, and rubella vaccine–associated inflammatory bowel disease or autism in a 14-year prospective study. Lancet 1998; 351:1327–8.
  • Poland G et al. Adversomics: The Emerging Field of Vaccine Adverse Event Immunogenetics. Pediatr Infect Dis J. 2009; 28(5): 431–432.
  • Prevots DR, Ciofi degli Atti ML, Sallabanda A et al. Outbreak of Paralytic Poliomyelitis in Albania, 1996: High Attack Rate Among Adults and Apparent Interruption of Transmission Following Nationwide Mass Vaccination. Clin Infect Dis 1998; 26:19-25.
  • Price CS, Thompson WW, Goodson B et al. Prenatal and infant exposure to thimerosal from vaccines and immunoglobulins and risk of autism. Pediatrics. 2010;126:656-64.
  • Pruna D, Balestri P, Zamponi N et al. Epilepsy and vaccinations: Italian guidelines. Epilepsia 2013;54 Suppl 7:13-22.
  • Ray P, Hayward J, Michelson D et al. Encephalopathy after whole-cell pertussis or measles vaccination. Lack of evidence for a causal association in a retrospective case-control study. Pediatr Infect Dis J 2006;25:768–733.
  • Raz R, Roberts AL, Lyall K. Autism Spectrum Disorder and Particulate Matter Air Pollution before, during, and after Pregnancy: A Nested Case–Control Analysis within the Nurses’ Health Study II Cohort. Environ Health Perspect; DOI:10.1289/ehp.1408133 http://ehp.niehs.nih.gov/1408133/
  • Reif DM, McKinney BA, Motsinger AA et al. Genetic Basis for Adverse Events Following Smallpox Vaccination. J Infect Dis. 2008; 198(1): 16–22.
  • Reynolds AH, Joos HA. Eczema vaccinatum. Pediatrics. 1958;22:259-67.
  • RKI - Robert Koch Institut. TOKEN-Studie über Todesfälle bei Kindern im 2.–24. Lebensmonat. RKI 2011 http://www.rki.de/DE/Content/GBE/Erhebungen/WeitereEpiStudien/TOKEN__Studie/token__node.html
  • Roper MH et al. Tetanus toxoid. In: Plotkin S, Orenstein WA, Offit PA (Eds.) Vaccines. Saunders 2013.
  • Rosenlund H, Bergström A, Alm JS et al. Allergic disease and atopic sensitization in children in relation to measles vaccination and measles infection. Pediatrics 2009;123:771-8.
  • Sandin S, Lichtenstein P, Kuja-Halkola R et al. The familial risk of autism. JAMA 2014;311:1770-1777.
  • Schendel DE, Grønborg TK, Parner ET et al. The Genetic and Environmental Contributions to Autism. Looking Beyond Twins. JAMA 2014;311:1738-1739.
  • Schmitz R, Poethko-Nueller C, Reiter S, Schlaud M. Vaccination status and health in children and adolescents. Deutsches Aerzteblatt International 2011;108:99-104.
  • Schneeweiss B, Pfleiderer M, Keller-Stanislawski B. Impfsicherheit heute. Deutsches Aerzteblatt 2008;105:590-5.
  • Schonberger LB, Bregman DJ, Sullivan-Bolyai JZ, et al. Guillain-Barre syndrome following vaccination in the National Influenza Immunization Program, United States, 1976–1977. Am J Epidemiol. 1979; 110:105–123.
  • Sørup S, Benn CS, Poulsen A et al. Live Vaccine Against Measles, Mumps, and Rubella and the Risk of Hospital Admissions for Nontargeted Infections. JAMA 2014;311:826-835.
  • Spycher BD, Silverman M, Egger M et al. Routine vaccination against pertussis and the risk of childhood asthma: a population-based cohort study. Pediatrics 2009;123:944-50.
  • Stanley SL Jr, Frey SE, Taillon-Miller P, et al. The immunogenetics of smallpox vaccination. J Infect Dis 2007;196:212-9.
  • Stehr-Green P, Tull P, Stellfeld M, et al. Autism and thimerosal-containing vaccines: lack of consistent evidence for an association. Am J Prev Med 2003;25:101-6.
  • Stojanov S, Liese J, Belohradsky BH. Hospitalization and complications in children under 2 years of age with Bordetella pertussis infection. Infection 2000;28:106-10.
  • Stoner R, Chow ML, Boyle MP et al "Patches of disorganization in the neocortex of children with autism" N Eng J Med 2014; 370: 1209-1219.
  • Stratton K et al. Immunization safety Review. SV40 contamination of polio vaccine and cancer. Institute of Medicine 2002. The National Academies Press, Washington DC www.iom.edu
  • Strauss JH, Strauss EG. Viruses and human disease. Academic Press, 2008.
  • Strickler H. Immunization safety review. Epidemiological evidence regarding a causal association between SV40-contaminated poliovirus vaccines and human cancer. Institute of Medicine 2002 www.iom.edu
  • Strömland K, Nordin V, Miller M, et al. Autism in Thalidomide Embryopathy: A Population Study. Developmental Med Child Neurol 1994;36:351-356.
  • Sun Y, Christensen J, Hviid A et al. Risk of febrile seizures and epilepsy after vaccination with diphtheria, tetanus, acellular pertussis, inactivated poliovirus, and Haemophilus influenzae type B. JAMA. 2012;307:823-31.
  • Tani C, Stella M, Donnarumma D et al. Quantification by LC–MSE of outer membrane vesicle proteins of the Bexsero vaccine. Vaccine 2014;32:1273-1279.
  • Taylor B, Miller E, Farrington CP et al. Autism and measles, mumps, and rubella vaccine: no epidemiological evidence for a causal association. Lancet 1999;353:2026-29.
  • Taylor B et al. Measles, Mumps and rubella vaccination and bowel problems or developemental regression in children with autism: population study. BMJ 2002;324:393–396.
  • Taylor LE, Swerdfeger AL, Eslick GD. Vaccines are not associated with autism: an evidence-based meta-analysis of case-control and cohort studies. Vaccine 2014;32:3623-9.
  • Thompson W et al. Early thimerosal exposure and neuropsychological outcomes at 7 to 10 years. NEJM 2007;357:1281-1292.
  • Tozzi AE, Bisiacchi P, Tarantino V et al. Neuropsychological Performance 10 Years After Immunization in Infancy With Thimerosal-Containing Vaccines Pediatrics 2009;123:475 – 482
  • Traversa G, Spila-Alegiani S, Bianchi C, Ciofi degli Atti M, Frova L, et al. Sudden Unexpected Deaths and Vaccinations during the First Two Years of Life in Italy: A Case Series Study. PLoS ONE 2011;6:e16363
  • Uhlmann V, Martin CM, Sheils O, Pilkington L, Silva I, Killalea A, Murch SB, Walker-Smith J, Thomson M, Wakefield AJ, O'Leary JJ. Potential viral pathogenic mechanism for new variant inflammatory bowel disease. Mol Pathol 2002;55:84-90.
  • United States Court of Federal Claims. Theresa and Michael Cedillo vs. Secretary of Health and Human Services. Docket Number 98-916V. Washington, June 22, 2007.
  • Uno Y, Uchiyama T, Kurosawa M et al. The combined measles, mumps, and rubella vaccines and the total number of vaccines are not associated with development of autism spectrum disorder: the first case-control study in Asia. Vaccine 2012;30:4292-8.
  • Uno Y, Uchiyama T, Kuerosawa M et al. Early exposure to the combined measles–mumps–rubella vaccine and thimerosal-containing vaccines and risk of autism spectrum disorder. Vaccine 2015 http://dx.doi.org/10.1016/j.vaccine.2014.12.036.
  • Vennemann MM, Hoffgen M, Bajanowski T, Hense HW, Mitchell EA. Do immunisations reduce the risk for SIDS? A meta-analysis. Vaccine. 2007;25:4875-9.
  • Veronesi R, Correia A, Ferreira H, et al. Naturally acquired immunity: further evidence in humans and animals. In: Proceedings of the fourth international conference on tetanus; 1975 April 6–12; Dakar, Senegal. Lyon: Fondation Merieux; 1975. p. 613–26.
  • Verstraeten T, et al. Safety of thimerosal-containing vaccines: a two-phased study of computerized health maintenance organization databases. Pediatrics 2003;112:1039-1048.
  • Vogt H, Bråbäck L, Kling AM et al. Pertussis immunization in infancy and adolescent asthma medication. Pediatrics. 2014;134:721-8.
  • Wagner KS, White JM, Neal S et al. Screening for Corynebacterium diphtheriae and Corynebacterium ulcerans in patients with upper respiratory tract infections 2007–2008: a multicentre European study. Clin Microbiol Infect 2011; 17: 519–525.
  • Wakefield AJ, Murch SH, Anthony A, et al. Ileal-lymphoid-nodular hyperplasia, non-specific colitis, and pervasive developmental disorder in children. Lancet 1998;351:637-641.
  • Walker CK, Krakowiak P, Baker A et al. Preeclampsia, Placental Insufficiency, and Autism Spectrum Disorder or Developmental Delay. JAMA Pediatr 2014 doi:10.1001/jamapediatrics.2014.2645.
  • Wassilak S, Oblapenko G, Dittmann S. Progress in Europe towards the goal of poliomyelitis eradication. Eurosurveillance – European Communicable Disease Bulletin 1997;2(5):39 – 41.
  • Wiznitzer M. Dravet syndrome and vaccination: when science prevails over speculation. Lancet Neurology 2010;9:559-561.
  • World Health Organization 1995. Expanded Programme on Immunization. Diphteria epidemic in the Newly Independent States of the former USSR, 1990 - 1994. Weekly Epidem Record 1995; 20: 141-44.
  • World Health Organization 1996. Expanded Programme on Immunization. Update: Diphteria epidemic in the Newly Independent States of the former USSR, January 1995 – March 1996. Weekly Epidem Record 1996; 20: 245-50.
  • World Health Organization 1997 (a). Lack of evidence that hepatitis B vaccine causes multiple sclerosis. Weekly Epidem Record, 1997; 21: 149-52.
  • World Health Organization 1997 (b). International Programme on Chemical Safety. Environmental Health Criteria No. 194, Aluminium, Geneva.
  • World Health Organization 2000. WHO air quality guidelines for Europe, 2nd edition, 2000 http://www.euro.who.int/
  • World Health Organization. Safety monitoring of medicinal products. Reporting system for the general public. Geneva, 2012. http://www.who.int
  • World Health Organization. Fact sheet. Observed rate of vaccine reactions. Varicella zoster virus vaccine. June 2012 http://www.who.int/vaccine_safety/initiative/tools/Varicella_Zoster_Vaccine_rates_information_sheet.pdf?ua=1.